Historical of NADH and Anti-Aging

Historical Background

NADH (Nicotinamide Adenine Dinucleotide) was first discovered in 1906 by British biochemists Arthur Harden and William Young. However, the significant role of NADH in cellular metabolism and energy production wasn't deeply understood until the mid-20th century.

In 1953, scientist Fritz Lipmann received the Nobel Prize in Physiology or Medicine for discovering NADH's function as a crucial coenzyme in cellular respiration. This marked the beginning of serious studies on NADH in terms of medical applications.

NADH and Anti-Aging

According to a 2014 study by Imai and Guarente, interest in using NADH for anti-aging began in the late 1990s when researchers started to understand the roles of NAD+ and NADH in metabolism and DNA repair processes.

Anti-Aging Mechanisms of NADH

1. Cellular Energy Restoration
   According to Ying's 2008 research, NADH is an important electron carrier in the ATP production process, which is the main energy source for cells. Increasing NADH levels helps improve energy production efficiency, allowing cells to function better despite aging.
2. Antioxidant Properties
   Studies by Belenky et al. in 2007 indicated that NADH has antioxidant properties and helps reduce cell damage from oxidative reactions. This reduction in damage helps slow down cellular deterioration.

3. Stimulation of DNA Repair
    Research by Fang et al. in 2016 stated that NADH plays an important role in activating the PARP enzyme, which helps repair damaged DNA. Efficient DNA repair can help reduce the accumulation of genetic abnormalities associated with cellular deterioration.

4. Activation of Sirtuins
   Research by Bonkowski and Sinclair in 2016 identified that NAD+ stimulates the function of Sirtuin proteins, which play a crucial role in controlling cell lifespan. Sirtuins help regulate the expression of genes related to aging and longevity.

Challenges and Future of NADH

Although research results in animal studies are interesting, applications in humans still require additional studies. The main challenges are:

• Finding efficient methods to increase NAD+/NADH levels in the human body

• Studying long-term side effects of supplementing with NADH or NAD+ precursors

• Developing methods to efficiently deliver NADH to target cells

But if you don't want to wait, you can choose products that supplement NADH in the body, but you must choose ones that are safe, meet standards, and have international quality certifications. They should also have Thai labels and proper Thai FDA approval to ensure you're getting quality, 100% genuine products.