
The history of FMD or Fasting Mimicking Diet is a concept developed by Dr. Valter Longo, a biology researcher and aging expert from the University of Southern California, USA. Dr. Longo has long studied the effects of fasting on health and lifespan, and has developed FMD as another dietary approach that yields results similar to IF (Intermittent Fasting), allowing the body to benefit from fasting without actually fasting.
Helps regenerate cells and stimulate the Autophagy process
Reduces inflammation in the body
Improves metabolic function
Helps control weight and reduce body fat
May reduce the risk of certain chronic diseases such as diabetes and heart disease
May slow aging and increase lifespan
FMD is typically done for 5 consecutive days
During these 5 days, calories are limited to about 34-54% of normal intake (800-1100 kcal)
The diet should be high in fat, low in carbohydrates, and low in protein
Should mainly consume plant-based foods such as vegetables, nuts, and healthy oils
Drink sufficient plain water and calorie-free herbal teas
After 5 days, gradually return to normal eating

A 2017 study by Wei et al. found that FMD helped reduce body weight, abdominal fat, and blood pressure in healthy adults
Research on mice by Brandhorst et al. in 2015 found that FMD may slow aging and reduce the risk of cancer and diabetes
A 2019 study by Choi et al. showed that FMD may help improve blood sugar control in patients with type 2 diabetes
However, this dietary approach may not be suitable for everyone. Those with pre-existing conditions should consult with experts or their treating physicians before doing FMD to avoid any potential adverse effects.
References
Wei, M., Brandhorst, S., Shelehchi, M., Mirzaei, H., Cheng, C. W., Budniak, J., ... & Longo, V. D. (2017). Fasting-mimicking diet and markers/risk factors for aging, diabetes, cancer, and cardiovascular disease. Science translational medicine, 9(377), eaai8700.
Brandhorst, S., Choi, I. Y., Wei, M., Cheng, C. W., Sedrakyan, S., Navarrete, G., ... & Longo, V. D. (2015). A periodic diet that mimics fasting promotes multi-system regeneration, enhanced cognitive performance, and healthspan. Cell metabolism, 22(1), 86-99.
Choi, I. Y., Piccio, L., Childress, P., Bollman, B., Ghosh, A., Brandhorst, S., ... & Longo, V. D. (2019). A diet mimicking fasting promotes regeneration and reduces autoimmunity and multiple sclerosis symptoms. Cell reports, 27(10), 2911-2925.